Here’s a full preview and analysis for Arizona Cardinals at Indianapolis Colts — Week 6 — predictions, betting angles, and key storylines to watch.

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Matchup Overview

• Date & Time: Sunday, October 12, 2025 — 1:00 pm ET
• Location: Lucas Oil Stadium, Indianapolis
• Records: Cardinals 2–3 | Colts 4–1
• Line / Odds (Early): Colts –6.5; Total (Over/Under) ~ 47.5 (SI)
• Moneyline: Colts ~ –275, Cardinals ~ +225 (varies by sportsbook) (SI)

Indianapolis enters as a clear favorite, riding momentum after a dominant 40–6 win over Las Vegas. (bigal.com) Arizona, meanwhile, is in a rough stretch — three straight losses, including blown leads in late-game situations. (SI)

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Strengths & Weaknesses

Indianapolis Colts

Strengths

1. Balanced Offense & Efficient Play
   Daniel Jones has been solid, making smart throws and limiting mistakes. (SI) The Colts have the personnel to punish both through the air and on the ground. (bigal.com)
2. Momentum & Confidence
   The team built confidence with their blowout win over the Raiders. (bigal.com)
3. Home Field Edge
   Playing at Lucas Oil Stadium gives a boost in a game where they are favored.

Weaknesses / Risks

• Injury Concerns
  Some key players are listed as questionable (e.g. Alec Pierce, Kenny Moore II) (SI)
• Overconfidence / Complacency
  After a big win, the danger is overlooking a struggling opponent that still has playmakers.

Arizona Cardinals

Strengths

• Big-Play Ability with Kyler Murray
  When healthy, Murray can flip a game with athleticism, designed runs, or deep passes.
• Desire to Bounce Back
  After a series of disappointing collapses, there’s a desperation factor that sometimes yields sharper play.

Weaknesses

1. Late-Game Collapses
   The Cardinals have struggled to close out games, especially under pressure in the 4th quarter. (SI)
2. Inconsistent Offense
   Outside of Murray’s flashes, the supporting cast has been streaky.
3. Injury & Depth Issues
   The injury report lists several questionable players (e.g. Murray listed questionable) (SI)

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Betting Trends & Angles

• The UNDER has hit in many of Arizona’s recent road games. (SI)
• Colts are 4–1 ATS in their last five games. (SI)
• Cardinals are profitable ATS when facing AFC foes, historically. (SI)
• In the head-to-head series, many recent games have gone UNDER. (SI)

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Prediction & Picks

I expect the Colts to control this game. Their defense should force consistency issues from Arizona, and their offense is in a steadier groove.

• Spread Pick: Colts –6.5
• Moneyline Pick: Colts
• Over/Under: Lean UNDER 47.5

Projected Score (my guess): Colts 30, Cardinals 16

Let me know if you want player props, live odds closer to kickoff, or analysis for your preferred sportsbook.