Cardinals’ Kyler Murray misses practice with foot injury ahead of Colts clash

In a troubling development for the Arizona Cardinals, starting quarterback Kyler Murray sat out practice Wednesday due to a foot injury, putting his status for Sunday’s showdown with the Indianapolis Colts in doubt. (Reuters)

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What Happened & Injury Background

Murray’s foot issue seems to stem from an incident in last week’s narrow 22-21 loss to the Tennessee Titans. During that game, a botched shotgun snap struck him in the face mask, triggering a scramble and a fumble. After the play, Murray exited the field, missed two snaps, then rejoined the game—albeit clearly favoring the foot at times. (AP News)

Head coach Jonathan Gannon confirmed Murray would not practice Wednesday and termed his condition “day-to-day.” (NFL.com)

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What This Means for the Cardinals

Offensive Impact

Murray has been a dual threat this season, both as a passer and a runner. He’s completed 68.3% of his throws for 962 yards with six touchdowns and three interceptions in five starts, while also leading the team in rushing with 173 yards and a score. (Reuters)

If he can’t play, it would be a major blow to Arizona’s offensive game plan, which leans heavily on play-action, mobility, and using Murray’s legs to extend plays. (SI)

Backup Option: Jacoby Brissett

If Murray is inactive, veteran Jacoby Brissett stands ready as the likely starter. Brissett has already seen brief action in this same game vs. the Titans. (Reuters)

Gannon praised Brissett as a “true pro” and emphasized that every quarterback must be ready to step in at a moment’s notice. (NFL.com)

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The Stakes in Week 6 vs. Colts

• The Cardinals are reeling, losing three straight games—each by a last-second field goal. (AP News)
• Arizona’s passing offense ranks 30th in the NFL, averaging just 170.2 yards per game—a stat likely to worsen without Murray under center. (AP News)
• The Colts, meanwhile, currently stand at 4-1 and are among the tougher matchups on the schedule. (ClutchPoints)

A win in Indianapolis could steady Arizona’s ship; a loss could deepen the hole. But everything hinges on Murray’s health status.

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Outlook & What to Watch This Week

• Keep an eye on the team’s injury reports and practice participation over the next few days—Murray’s “day-to-day” tag suggests the Cardinals won’t rush any decision. (Reuters)
• Watch for how play-calling might change if Brissett starts—likely more conservative, less reliance on designed quarterback runs.
• The offensive line and receiving corps will need to be especially sharp to ease the transition in case Murray can’t go.

If you like, I can also pull up a projected depth chart or simulate how the offense might look under Brissett. Do you want me to do that?

• Reuters
• SB Nation
• Revenge of the Birds